Synthesis and Biological Activity of Some Trifluoromethyl Derivatives of 5-tert-Butyl-2-furylmethylideneanilines and Their Silyl Analogs |
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Authors: | I. Iovel L. Golomba L. Zvejniece I. Shestakova E. Lukevics |
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Affiliation: | (1) Latvian Institute of Organic Synthesis, Riga, LV-1006 |
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Abstract: | We have synthesized the corresponding aldimines by condensation of 5-tert-butylfurfural and its trimethyl- and triethylsilyl analogs with 2-, 3-, and 4-trifluoromethylanilines in the presence of 4 molecular sieves. We have studied their neurotropic and antitumor activity. The phenamine motor activity test showed that tert-butyl derivatives exhibit high efficacy and also shorten the ethanol narcosis time. Some silyl derivatives exhibit significant anti-corazole activity. The tert-butyl derivatives have high cytotoxicity toward human lung fibrosarcoma cells (the 3-trifluoromethyl-substituted derivative) and mouse hepatoma cells (the 2-trifluoromethyl-substituted derivative). |
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Keywords: | furan Schiff's bases silyl derivatives trifluoromethylanilines neurotropic activity cytotoxicity |
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