1-β-D-呋喃核糖基-1,2,4-三唑-3-酰胺铂(II)配合物的合成 |
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引用本文: | 裴文,孙莉.1-β-D-呋喃核糖基-1,2,4-三唑-3-酰胺铂(II)配合物的合成[J].化学学报,2002,60(11):2074-2077. |
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作者姓名: | 裴文 孙莉 |
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作者单位: | 浙江工业大学化学工程学院,杭州,310014 |
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摘 要: | 在缓冲液中,利用1-β-D-呋喃核糖基-1,2,4-三唑-3-酰胺(ribavirin)和1- (2'-脱氧-β-D-呋喃核糖基)-1,2,4-三唑-3-酰胺(deoxyribavirin)作为配体 ,分别与cis-Pt(DMSO)_2Cl_2]或KPt(DMSO)Cl_3]进行配位反应,得到了高产率 的Pt-(N~4,N~7-ribavirin)(DMSO)Cl] (1)和Pt(N~4,N~7-deoxyribavirin) (DMSO)Cl] (2)两种配合物。1-(2'-脱氧-β-D呋喃核糖基)-1,2,4-三唑-3-酰 胺的合成是由1-β-D-呋喃核糖基-1,2,4-三唑-3-酰胺与1,3-二氯-1,1,3,3- 四异丙基二硅氧烷保护,在1-甲基咪唑存在下与硫代苯氧基碳酰氯反应,再用tri- n-butyltin hydride和AIBN还原,四丁基氟化铵的四氢呋喃溶液脱去保护基四步反 应完成的。
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关 键 词: | 铂络合物 三氮唑核苷 呋喃 P 酰胺 P 酰氯 咪唑 |
修稿时间: | 2002年2月26日 |
Preparation of Platinum(Ⅱ) Complexes with 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide and Its Deoxyanalogue |
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Institution: | College of Chemical Engineering, Zhejiang University of Technology, Hangzhou(310014) |
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Abstract: | Platinum(II) complexes of Pt(N~4,N~7-ribavirin)(DMSO)Cl] and Pt (N~4,N~7-deoxyribavirin)-(DMSO)Cl] were prepared by the reactions of cis-Pt(DMSO)_2Cl_2] or KPt (DMSO)Cl_3] with 1-β-D-ribofuranosyl-1,2, 4-triazole-3-carboxamide and its deoxyanalogue in buffer with good yields. The preparation of 1-(2'-deoxy-β-D-ribofuranosyl)-1,2,4- triazole-3-carboxamide was also performed through a four-step procedure, including protection of 3',5'-dihydroxyl group of ribavirin with 1,3- dichloro-1,1,3,3-tetraisopropyl-disiloxane, phenoxythiocarbonylation of the 2'-hydroxyl group of 3',5'-O-TPDS-ribavirin with phenoxythiocarbonylchloride, reduction of 2'-O-phenoxythiocarbonyl ester of 3',5'-O-TPDS-ribavirin with trin-butyltin hydride and AIBN, and deprotection of 3',5'-O-TPDS-ribavirin with tetrabutylammonium fluoride in THF. |
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Keywords: | PLATINUM COMPLEX TRIBAVIRIN FURAN P AMIDES P ACYL CHLORIDES GLYOXALINE |
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