A new visual investigation into nanogold-based genechip assay by atomic force and scanning tunneling microscope |
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| Authors: | Dayong Gu Weidong Xie Zhen Li Weiping Lu Yuanguo Zhou and Minghui Ji |
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| Institution: | [1]Research Institute of Disease Control and Prevention, Shenzhen Internation Travel Healthcare Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen 518045, China [2]Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China [3]Department of Chemica Defence, Navy Submarine Academy, PLA, Qingdao 266071, China [4]Department 7, Research Institute of Surgery and Daping Hospital, The Third Military Medical University, Chongqing 400042, China [5]Research Institute of Disease Control and Prevention, Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen 518045, China |
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| Abstract: | Conformations of surface atoms in various stages of nanogold-based genechip testing are scanned by the atomic force and scanning tunneling microscope. We intuitively observe the process and differences in probe combination, nucleic acid hybridization, and silver staining, which might be useful to validate the assay method of genechip. We hope to use this technology to make the other invisible chemical or biochemical reaction become visible and convincible in the future. |
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