In vivo whole-body imaging of optical agent dynamics using full angle fluorescence diffuse optical tomography |
| |
Authors: | Xin Liu Fei Liu Daifa Wang Jing Bai |
| |
Institution: | Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China |
| |
Abstract: | Dynamic fluorescence diffuse optical tomography (FDOT) is important in drug deliver research. In this letter, we first image the metabolic processes of micelles indocyanine green throughout the whole body of a nude mouse using the full-angle FDOT system with line illumination (L-FDOT). The resolution of L-FDOT is evaluated using phantom experiment. Next, in vivo dynamic tomographic images (100 frames; approximately 170 min) of mouse liver and abdomen are shown and cross-validated by planar fluorescence reflectance imaging in vitro. Results provide evidence on applicability of the tomographic image wholebody biological activities in vivo on minute timescale (approximately 1.7 min) using L-FDOT. |
| |
Keywords: | |
本文献已被 CNKI 维普 等数据库收录! |
|