Thermal degradation of platinum(IV) precursors to antitumor drugs |
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Authors: | B A Howell P Chhetri A Dumitrascu K N Stanton |
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Institution: | (1) Center for Applications in Polymer Science, Central Michigan University, Mt. Pleasant, MI, USA;(2) Department of Chemistry, Central Michigan University, Mt. Pleasant, MI 48859-0001, USA |
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Abstract: | Organoplatinum antitumor agents are very effective, broad-spectrum drugs used for the treatment of a variety of cancerous
conditions. The two most prominent of these, Cisplatin cis-diamminodichloroplatinum(II)] and Carboplatin diammino(1,1-cyclobutanedicarboxylato)platinum(II)], are large scale commercial
successes. The third, Oxaliplatin ((trans-1,2-diamminocyclohexane)oxalato)platinum(II)], is now commercially available. The administration of all these drugs is accompanied
by severe side effects. For Cisplatin, the most debilitating of these is kidney damage and extreme nausea. Several approaches
to generate drug-release formulations that might mitigate toxic side effects have been explored. Now, platinum(IV) compounds
which are more inert than platinum(II) compounds, and consequently less toxic, but which may be reduced to platinum(II) species
within the cell are being evaluated for effectiveness in the treatment of cancer. The thermal stability of several precursors
to compounds of this kind has been examined by thermogravimetry. In general, these materials lose ligands sequentially to
generate a residue of platinum. This behavior may be generally useful for the characterization of such materials. |
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