| 摘 要： | Alpha-1-antitrypsin (Pi) types and subtypes in a Chinese population of 1049 unrelatedindividuals in Beijing were determined by separator isoelectric focusing. The low activityPi variant S and the deficient Pi variant Z, common in most Caucasian populations, are ab-sent in the Chinese population. The frequent Pi variant found in the Chinese population isa neutral mutant, Etokyo, which was only found in Japanese before. Thus, it is concludedthat, as a predisposition of obstructive or some other lung diseases and liver diseases, thegenetic determined deficiency of alpha-1-antitrypsin in Chinese is not so important as in mostCaucasian populations.
|
