| 两亲性线性-超支化多臂共聚物在水溶液中自组装为阳离子囊泡的研究 |
| |
| 引用本文： | 田华雨,夏加亮,林浩,陈磊,陈学思,李悦生,景遐斌.两亲性线性-超支化多臂共聚物在水溶液中自组装为阳离子囊泡的研究[J].高等学校化学学报,2006,27(9):1771-1774. |
| |
| 作者姓名： | 田华雨 夏加亮 林浩 陈磊 陈学思 李悦生 景遐斌 |
| |
| 作者单位： | 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春,130022 |
| |
| 基金项目： | 国家自然科学基金;国家自然科学基金 |
| |
| 摘 要： | 利用两亲性线性-超支化多臂共聚物聚乙二醇-聚乙烯亚胺-聚谷氨酸苄酯(PEG-PEI-PBLG)在水溶液中自组装为阳离子囊泡. 利用透射电镜、动态光散射、静态光散射和zeta电位仪对囊泡结构进行了表征. PEG-PEI-PBLG囊泡具有双分子层结构, 壁厚5~10 nm, 直径在100 nm左右. 由于PEI在水溶液中的质子化作用, 囊泡表面携带有正电荷, 其表面电势为＋25。2 mV, 因此PEG-PEI-PBLG阳离子囊泡具有担载负电性蛋白的能力.
|
| 关 键 词： | 超支化多臂共聚物 自组装 囊泡 聚乙烯亚胺 |
| 文章编号： | 0251-0790（2006）09-1771-04 |
| 收稿时间： | 12 13 2005 12:00AM |
| 修稿时间： | 2005-12-13 |
Self-assembly of Amphiphilic Linear-hyperbranched Multi-arm Copolymer into Cationic Vesicles |
| |
| TIAN Hua-Yu,XIA Jia-Liang,LIN Hao,CHEN Lei,CHEN Xue-Si,LI Yue-Sheng,JING Xia-Bin.Self-assembly of Amphiphilic Linear-hyperbranched Multi-arm Copolymer into Cationic Vesicles[J].Chemical Research In Chinese Universities,2006,27(9):1771-1774. |
| |
| Authors: | TIAN Hua-Yu XIA Jia-Liang LIN Hao CHEN Lei CHEN Xue-Si LI Yue-Sheng JING Xia-Bin |
| |
| Institution: | State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China |
| |
| Abstract: | Amphiphilic linear-hyperbranched multi-arm copolymer poly(ethylene glycol)-polyethylenimine-poly(γ-benzyl L-glutamate)(PEG-PEI-PBLG) can self-assemble into cationic vesicles in aqueous solution. TEM, DLS, SLS and zeta potential measurement were used to characterize the structure of the PEG-PEI-PBLG vesicles. The vesicles were constituted of 5—10 nm bimolecular layers with average diameter in 100 nm and surface zeta potential of ＋25.2 mV. The positive charges on vesicles surface were caused by the protonation of PEI in aqueous solution. The cationic vesicles have an ability to carry negatively charged proteins. |
| |
| Keywords: | Hyperbranched multi-arm copolymer Self-assembling Vesicles Polyethylenimine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《高等学校化学学报》浏览原始摘要信息 |
| 点击此处可从《高等学校化学学报》下载免费的PDF全文 |
