A new diastereoselective multicomponent, one-pot strategy for the synthesis of 3-substituted isoindolinones via efficient C-C bond formation |
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| Authors: | Jie-Ping Wan Hui Mao An-Xin Wu |
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| Affiliation: | a Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China
b Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, PR China |
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| Abstract: | A new three-component reaction among o-phthalaldehyde, N-alkyl/aryl substituted urea, and an aromatic aldehyde has been developed at ambient condition, and a class of isoindolinones with novel C-3 substitution were conveniently synthesized. The general diastereomeric excess as high as over 99% of the products indicated the excellent stereoselectivity posed in this multicomponent reaction. |
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| Keywords: | Multicomponent One-pot 3-Substituted isoindolinones C-C bond formation |
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