Practical synthesis of novel purine analogues as Hsp90 inhibitors |
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Authors: | Teresa Semeraro Fabrizio Manetti |
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Affiliation: | Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro snc, 53100 Siena, Italy |
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Abstract: | The development of a straightforward synthesis of 4-amino-6-benzyl-6H-pyrrolo[3,4-d]pyrimidine and 7-amino-2-benzyl-2H-pyrazolo[4,3-d]pyrimidine derivatives allowed for the preparation of a small family of potential Hsp90 inhibitors. Some of the newly synthesized compounds showed Hsp90 inhibitory activity in preliminary biological assays. |
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