Desulfurization of sultams with simultaneous methylenation |
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| Authors: | Victor O Rogachev Sandra Merten Olga Kataeva Peter Metz |
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| Institution: | a Department of Chemistry, Technische Universität Dresden, Bergstraße 66, D-01069 Dresden, Germany
b Department of Organic Chemistry, Tomsk Polytechnic University, pr. Lenina 30, 634050 Tomsk, Russia |
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| Abstract: | Alkylation of γ- and δ-sultams with (iodomethyl)trimethylsilane followed by treatment of the resultant silanes with tetrabutylammonium fluoride gave rise to sulfur-free unsaturated amines. In particular, N-THP substituted sultams were found to be useful substrates for the alkylation event. A corresponding one-pot transformation involving sultam α-alkylation with (iodomethyl)magnesium chloride is also reported. |
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| Keywords: | Alkenylation Alkylation Desulfurization Sultams |
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