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Synthesis of tetracyclic dioxygenated isoquinolines and their cytotoxic activity |
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| Authors: | Manel Romero Pierre Renard |
| Institution: | a Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain b Laboratoires Servier, Courbevoie Cedex, Paris, France |
| Abstract: | An efficient synthesis of new dioxygenated isoquinolines is reported. The novelty of this approach derives from its use of tricyclic-nitril (3) as a building block in a synthetic sequence of seven steps for the preparation of the tetracyclic isoquinoline (14) and its derivatives. The isoquinoline 16 was 10-fold more active against leukemia L1210 than the corresponding tetrahydroisoquinoline 14. |
| Keywords: | Polycyclic compounds Phenethylamine derivatives Dioxygenated isoquinoline Antitumor compounds |
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