Effective synthetic routes to activated pyrrolo[3,2,1-hi]indoles |
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Authors: | Jumina |
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Institution: | School of Chemistry, University of New South Wales, UNSW Sydney NSW 2052, Australia |
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Abstract: | Pyrrolo3,2,1-hi]indoles have been formed by the aldol cyclisation of 7-formyl-N-indolylacetates. The synthetic sequence incorporates three steps from suitably activated indoles: these are alkylation at nitrogen with a bromoacetic ester, formylation at C7 and an aldol condensation between these two substituents. An X-ray crystal structure of pyrrolo3,2,1-hi]indole 24 is described. |
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Keywords: | Indoles Pyrroloindoles Aldol reaction Cyclisation reactions |
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