Synthesis of substituted salicylamines and dihydro-2H-1,3-benzoxazines |
| |
Authors: | Hany F. Anwar Trond Vidar Hansen |
| |
Affiliation: | a School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068, Blindern, N-0316 Oslo, Norway b Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N-0315 Oslo, Norway |
| |
Abstract: | Phenols were converted to their magnesium salts with the MgCl2-Et3N base system and subsequently reacted with Eschenmoser's salt, affording N,N-dimethyl substituted benzylamines in high to excellent yields. A series of mono N-substituted benzylamines were prepared in one-pot syntheses by ortho-formylation of phenols to corresponding salicylaldehydes, which in turn reacted with amines to imines. The imines were subsequently reduced to mono N-substituted benzylamines. Some of these benzylamines were further converted, without work-up, to mono N-substituted dihydro-2H-1,3-benzoxazines. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|