Synthesis of cyclophospho-glucoses and glucitols |
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| Authors: | EJ Amigues S Ju ME Migaud |
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| Institution: | a School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast, BT9 5AG Northern Ireland, UK
b College of Liberal Arts and Sciences, Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA |
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| Abstract: | The syntheses of cyclophosphodiesters of 5-C-(hydroxymethyl)-hexoses and hexitols and of 6-C-(hydroxymethyl)-hexoses are reported, along with that of 6-deoxy-gluco-heptose 7-phosphate. These compounds proved to be reasonable substrate mimics and show inhibitory activity against human d-myo-inositol 3-phosphate synthase. |
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