Synthesis of 3′-deoxy-3′-C-methyl-β-d-ribonucleoside analogs |
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| Authors: | Sarah Couturier,Gilles Gosselin,Christian Pé rigaud |
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| Affiliation: | a Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM 1-UM 2, Université Montpellier 2, Case Courrier 1705, Place E. Bataillon, 34095 Montpellier Cédex 05, France
b Laboratoires Idenix Sarl, Cap Gamma, 1682 rue de la Valsière, 34819 Montpellier Cédex 04, France |
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| Abstract: | 3′-Deoxy-3′-C-methyl-β-d-ribonucleoside analogs bearing the five canonical bases of nucleic acids have been synthesized. All these derivatives were prepared by glycosylation of the corresponding heterocyclic bases with a suitable peracylated 3-C-methyl sugar precursor. The synthesis of the 3-C-methyl sugar precursor is described following a new stereoselective synthetic pathway. |
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