Conjugate reduction of α,β-unsaturated esters and amides with tributyltin hydride in the presence of magnesium bromide diethyl etherate |
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Authors: | Satomi Hirasawa |
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Affiliation: | Department of Chemistry, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan |
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Abstract: | We report herein that the conjugate reduction of α,β-unsaturated esters and amides, such as aryl acrylates, pantolactone esters of acrylic acids, diethyl itaconate and N-crotonylcamphorsultam, with tributyltin hydride proceeded in moderate to high yields in the presence of magnesium bromide diethyl etherate. The effect of metal halide enhancing the yields is also described. |
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Keywords: | Conjugate reduction α,β-Unsaturated esters and amides Tributyltin hydride Lewis acid |
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