Synthesis of 5-arylhistidines via a Suzuki-Miyaura cross-coupling |
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Authors: | Vanessa Cerezo |
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Affiliation: | Laboratori d'Innovació en Processos i Productes de Síntesi Orgànica (LIPPSO), Departament de Química, Universitat de Girona, Campus de Montilivi, 17071 Girona, Spain |
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Abstract: | Microwave irradiation efficiently promoted the Suzuki-Miyaura reaction of a 5-bromohistidine with various arylboronic acids in the presence of a palladium catalyst. This methodology allowed the synthesis of histidines substituted at position 5 of the imidazole ring with a phenyl, a substituted phenyl, a pyridyl or a thienyl ring. The corresponding 5-arylhistidines were obtained in moderate to good yields. |
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Keywords: | Histidine Arylation Suzuki-Miyaura cross-coupling Microwave Biaryl compounds |
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