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Synthesis of phosphonomethoxyethyl or 1,3-bis(phosphonomethoxy)propan-2-yl lipophilic esters of acyclic nucleoside phosphonates |
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| Authors: | Silvie Vrbková Martin Dra?ínský |
| Institution: | Centre for Novel Antivirals and Antineoplastics, Gilead Sciences and IOCB Research Center, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic |
| Abstract: | A new alternative synthetic pathway towards mono and diesters of acyclic nucleoside phosphonates (PMEA, PMEC and PMEG) or 1,3-bis(phosphonomethoxy)propan-2-yl]adenine bearing one or two hexadecyloxypropyl ester groups (CH2)3O-n-C16H33 is reported. |
| Keywords: | Acyclic nucleoside phosphonates (ANPs) PMEA PMEC PMEG Alkoxyalkyl phosphonates Hexadecyloxypropyl ester groups Bisphosphonates Synthesis |
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