An efficient substituent dependent synthesis of congested pyridines and pyrimidines |
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Authors: | Ramendra Pratap Vishnu Ji Ram |
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Institution: | a Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India b Division of SAIF, Central Drug Research Institute, Lucknow 226 001, India |
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Abstract: | An efficient and versatile synthesis of various congested pyridines 3a-h, 6a,b, 8a-n, 10a-g, and 16a,b, and (pyrimidin-4-yl)acetonitriles 13a-g has been delineated by base catalyzed ring transformation of suitably functionalized 2H-pyran-2-ones 1a-h, 5, 7, and 15 by formamidine acetate 2a, acetamidine hydrochloride 2b, S-methylisothiourea 9a, pyrazol-1-yl-carboxamidine 9b, and arylamidine hydrochloride 12 separately in the presence of powdered KOH in dry DMF. |
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Keywords: | Pyridine Pyrimidine Amidine Ring transformation 2H-Pyran-2-ones |
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