Concise synthesis of two trisaccharides related to the saponin isolated from Centratherum anthelminticum |
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| Authors: | Santanu Mandal |
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| Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226001, UP, India |
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| Abstract: | Chemical synthesis of two trisaccharides related to the saponin isolated from Centratherum anthelminticum is reported. Stereoselective, high-yielding glycosylation strategies were developed using H2SO4 immobilized on silica for activation of trichloroacetimidate donors, or in conjunction with N-iodosuccinimide for activation of a thioglycoside. A late stage TEMPO-mediated oxidation was performed for the formation of the required uronic acid moiety. |
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