Synthesis of an indole containing KDR kinase inhibitor by tandem Sonogashira coupling-5-endo-dig-cyclization as a key step |
| |
| Authors: | Sanjay S. Palimkar |
| |
| Affiliation: | Division of Organic Chemistry: Technology, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, Maharashtra, India |
| |
| Abstract: | An efficient synthesis of the potent KDR kinase inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indol-2-yl]quinoline-2-(1H)-one using a Sonogashira coupling-5-endo-dig-cyclization strategy is described. |
| |
| Keywords: | Indol-2-yl quinoline-2-one Synthesis 5-endo-dig-Cyclization KDR kinase inhibitor |
| 本文献已被 ScienceDirect 等数据库收录！ |
