Eight new diterpenoids from soft coral Cespitularia hypotentaculata |
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Authors: | Ya-Ching Shen Ying-Ru Wu Kuang-Liang Lo Ashraf Taha Khalil |
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Affiliation: | a School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road Section 1, Taipei 100, Taiwan, ROC b Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, ROC c Department of Life Science, Fu-Jen University, No. 510, Chung-Cheng Road, Hsinchuang, 242 Taipei Hsien, Taiwan, ROC |
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Abstract: | Chemical investigation of the soft coral Cespitularia hypotentaculata resulted in the isolation of eight new diterpenes, cespihypotins E-L (1-8). The new metabolites comprise of six verticillene-type diterpenes, one cespitularane derivative, and one derivative with 14-membered lactone ring. The structures were determined through detailed spectroscopic analyses, especially high resolution ESIMS and 2D NMR techniques. The relative stereochemistry was deduced from NOESY spectrum and application of Mosher's ester technique. Immunomodulatory and antiviral activities of 1-8 were tested and evaluated. The biogenetic pathways for 1-8 were also proposed. |
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Keywords: | Cespitularia hypotentaculata Verticillene diterpenes Cespihypotins Immunomodulatory activity |
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