New diastereomeric bis-sesquiterpenes from Hainan marine sponges Axinyssa variabilis and Lipastrotethya ana |
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Authors: | Shui-Chun Mao Yue-Wei Guo Margherita Gavagnin Ernesto Mollo Rob van Soest |
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Affiliation: | a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Institutes for Biological Sciences, Chinese Academy of Sciences, 201203 Shanghai, PR China b Istituto di Chimica Biomolecolare (ICB), CNR, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy c Zoologisch Museum, University of Amsterdam, PO Box 94766, 1090 GT Amsterdam, The Netherlands |
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Abstract: | Three unprecedented diastereoisomeric dimers, cis-dimer A (1), cis-dimer B (2) and trans-dimer C (3), exhibiting a bis-bisabolene skeleton, and a new sesquiterpene, dehydrotheonelline (4), their potential precursor, have been isolated from the South China Sea sponges Axinyssa variabilis and Lipastrotethya ana, along with known related sesquiterpenes. The structure of the novel molecules has been determined by extensive NMR spectral analysis. |
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