Synthesis and molecular structure of spirocyclic 2-oxindole derivatives of 2-amino-4H-pyran condensed with the pyrazolic nucleus |
| |
| Authors: | Ruslan Gr. Redkin Leonid A. Shemchuk Oleg V. Shishkin |
| |
| Affiliation: | a National Pharmaceutical University, Pushkinska Street, 53, Kharkiv 61001, Ukraine
b STC Institute for Single Crystals, National Academy of Sciences of Ukraine, Lenin Avenue 60, Kharkiv 61001, Ukraine |
| |
| Abstract: | 4,3′-Spiro[(6-amino-5-R-3-methyl-2H,4H-pyrano[2,3-c]pyrazolo)-2′-oxindoles] were synthesized based on the three-component condensation of isatins with 3-methyl-pyrazolone-5 and respective methylene active nitriles in the presence of basic catalysts. The molecular structure of the resulting compounds was proved unambiguously by X-ray diffraction. |
| |
| Keywords: | 3-Spiro-2-oxindoles Pyrano[2,3-c]pyrazol Methylene active nitriles Michael reaction X-ray diffraction analysis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
