Highly selective hydroarylation of propiolic acid derivatives using a PtCl2/AgOTf catalytic system |
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| Authors: | Juzo Oyamada |
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| Institution: | Department of Chemistry and Applied Chemistry, Faculty of Science and Engineering, Saga University, Honjo-machi, Saga 840-8502, Japan |
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| Abstract: | Hydroarylation of propiolic acid derivatives with arenes in trifluoroacetic acid efficiently proceeded in the presence of PtCl2/AgOTf catalyst to give cis-cinnamic acid derivatives in good to high yields. This PtCl2/AgOTf-catalyzed reaction did not afford any 4-arylbuta-1,3-diene-1,3-dicarboxylic acid derivatives formed by Pd(OAc)2-catalyzed hydroarylation. The specific optimization of the catalytic hydroarylation and application to electron-rich arenes are reported. |
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| Keywords: | Hydroarylation Propiolic acid derivatives Platinum chloride Silver triflate Cinnamic acid derivatives |
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