The oxime bond formation as an efficient tool for the conjugation of ruthenium complexes to oligonucleotides and peptides |
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| Authors: | Mathilde Villien,Etienne Gicquel,Cé cile Moucheron,Pascal Dumy |
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| Affiliation: | a Département de Chimie Moléculaire, UMR CNRS 5250, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France
b Laboratoire de Chimie Organique et Photochimie, Université libre de Bruxelles (U.L.B.), B-1050 Bruxelles, Belgique |
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| Abstract: | A convenient method for the conjugation of ruthenium complex on oligonucleotides and peptides through chemoselective oxime linkage is reported. Novel Ru(II) complexes sustaining an aminooxy containing ligand were prepared and efficiently coupled with the oligonucleotides and peptides functionalized with the complementary reactive aldehyde group. The method described herein could be a useful tool for preparing a broad range of metal complex-oligonucleotide and peptide conjugates. |
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