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Effective esterification of carboxylic acids using (6-oxo-6H-pyridazin-1-yl)phosphoric acid diethyl ester as novel coupling agents |
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| Authors: | Ju-Eun Won Jeum-Jong Kim Min-Jung Kim Hyun-A. Chung Yong-Jin Yoon |
| Affiliation: | a Department of Chemistry and Environmental Biotechnology National Core Research center, Research Institute of Natural Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University, 900 Gazwa-dong, Jinju, Gyeongnam 660-701, Republic of Korea b Department of Chemistry, Research Institute of Natural Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University, 900 Gazwa-dong, Jinju, Gyeongnam 660-701, Republic of Korea |
| Abstract: | (6-Oxo-6H-pyridazin-1-yl)phosphoric acid diethyl esters (3) are efficient and selective coupling agents for equimolar esterification of carboxylic acids and alcohols. Esterification of aliphatic and aromatic carboxylic acids with aliphatic and aromatic alcohols using 3 afforded the corresponding esters chemoselectively in good to excellent yield. |
| Keywords: | (6-Oxo-6H-pyridazin-1-yl)phosphoric acid diethyl ester Coupling agent Carboxylic acid Pyridazinone Esterification |
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