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Synthesis and photophysics of an octathioglycosylated zinc(II) phthalocyanine |
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| Authors: | Aggarwal Amit Singh Sunaina Zhang Yazhou Anthes Mariah Samaroo Diana Gao Ruomei Drain Charles Michael |
| Institution: | a Department of Chemistry and Biochemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10065, USA b Department of Chemistry and Biochemistry, Jackson State University, 1400 J. R. Lynch Street, Jackson, Mississippi 39217, USA c Department of Chemistry, NYC College of Technology of the City University of New York, 300 Jay Street, Brooklyn, NY 11201, USA d The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA |
| Abstract: | A water soluble zinc(II) phthalocyanine symmetrically appended with eight thioglucose units was synthesized from commercially available hexadecafluorophthalocyaninatozinc(II) by controlled nucleophilic substitution of the peripheral fluoro groups. The photophysical properties and cancer cell uptake studies of this nonhydrolysable thioglycosylated phthalocyanine are reported. The new compound has amphiphilic character, is chemically stable, and can potentially be used as a photosensitizer in photodynamic therapy. |
| Keywords: | Phthalocyanine Photodynamic therapy Glucose Fluorescence Quantum yield |
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