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Spironaamidine, a new spiroquinone-containing alkaloid from the marine sponge Leucetta microraphis |
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| Authors: | Yumiko NagasawaHikaru Kato Henki Rotinsulu Remy EP MangindaanNicole J de Voogd Sachiko Tsukamoto |
| Institution: | a Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan b Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan c Faculty of Agriculture, Universitas Pembangunan Indonesia, Manado 95361, Indonesia d Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia e Netherlands Centre for Biodiversity Naturalis, PO Box 9517, 2300 RA Leiden, The Netherlands |
| Abstract: | Spironaamidine (1), a unique spiroquinone-containing alkaloid, was isolated from the marine sponge, Leucetta microraphis, along with two known imidazole alkaloids, naamidine H (2) and (9E)-clathridine 9-N-(2-sulfoethyl)imine (3). Spironaamidine (1) showed antimicrobial activity against Bacillus cereus. |
| Keywords: | Spiroquinone Alkaloid Leucetta microraphis Marine sponge |
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