Synthesis of 3,3-disubstituted oxetane building blocks |
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| Authors: | Daniele Vigo Luigi StasiStefania Gagliardi |
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| Affiliation: | a NiKem Research S.r.l., via Zambeletti 25, 20021 Baranzate, Italy
b Rottapharm|Madaus R&D Division, via Valosa di Sopra 9, 20052 Monza, Italy |
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| Abstract: | The synthesis of two different sets of 3,3-disubstituted oxetane building blocks is described. These molecules can be usefully incorporated in more complex structures to modulate their metabolic and physicochemical properties. The synthetic pathways are general and could be exploited for the synthesis of many other related derivatives. |
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| Keywords: | Oxetane Building blocks Bioisoster gem-Dimethyl replacement |
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