Application of the intramolecular isomerisation-aldolisation from allylic alcohols and allylic silyl ethers to the synthesis of indanones and indenones |
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| Authors: | Petrignet Julien Roisnel Thierry Grée René |
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| Institution: | Synthèse et Electrosynthèse Organiques CNRS UMR 6510, Université de Rennes 1, Avenue du Général Leclerc, 35042 Rennes Cedex, France. |
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| Abstract: | A new access to indanones was discovered through a one-step nickel or iron-mediated transposition of 2-hydroxyisobenzofurans. Starting from the corresponding silylenol ethers, a new one-pot tandem isomerisation-Mukaiyama aldol process was also developed. These versatile strategies will be useful for the preparation of various types of indanones and indenones. |
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| Keywords: | aldol reactions allylic alcohols indanones indenones iron nickel |
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