Targeted mutagenesis of the Sap47 gene of Drosophila: Flies lacking the synapse associated protein of 47 kDa are viable and fertile |
| |
| Authors: | Natalja Funk Sonja Becker Saskia Huber Marion Brunner and Erich Buchner |
| |
| Institution: | (1) Theodor Boveri-Institut f?r Biowissenschaften, Lehrstuhl f?r Genetik und Neurobiologie, Am Hubland, D-97074 W?rzburg, Germany;(2) GSF - Forschungszentrum f?r Gesundheit und Umwelt, Institut f?r Experimentelle Genetik, Ingolst?dter Landstr. 1, 85764 Neuherberg, Germany;(3) GSF - Forschungszentrum f?r Gesundheit und Umwelt, Institut f?r Humangenetik, Ingolst?dter Landstr. 1, 85764 Neuherberg, Germany |
| |
| Abstract: | Background Conserved proteins preferentially expressed in synaptic terminals of the nervous system are likely to play a significant role
in brain function. We have previously identified and molecularly characterized the Sap47 gene which codes for a novel synapse associated protein of 47 kDa in Drosophila. Sequence comparison identifies homologous proteins in numerous species including C. elegans, fish, mouse and human. First hints as to the function of this novel protein family can be obtained by generating mutants
for the Sap47 gene in Drosophila. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
