The conserved protein kinase-A target motif in synapsin of Drosophila is effectively modified by pre-mRNA editing |
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| Authors: | S?ren Diegelmann Vanessa Nieratschker Ursula Werner Jürgen Hoppe Troy Zars Erich Buchner |
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| Affiliation: | (1) Lehrstuhl f?r Genetik und Neurobiologie, Theodor Boveri Institut f?r Biowissenschaften der, Universit?t W?rzburg, W?rzburg, Germany;(2) Lehrstuhl f?r Physiologische Chemie, Theodor Boveri Institut f?r Biowissenschaften der, Universit?t W?rzburg, W?rzburg, Germany;(3) Division of Biological Sciences, University of Missouri-Columbia, Columbia, USA |
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| Abstract: | Background Synapsins are abundant synaptic vesicle associated phosphoproteins that are involved in the fine regulation of neurotransmitter release. The Drosophila member of this protein family contains three conserved domains (A, C, and E) and is expressed in most or all synaptic terminals. Similar to mouse mutants, synapsin knock-out flies show no obvious structural defects but are disturbed in complex behaviour, notably learning and memory. |
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