Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif |
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| Authors: | Ko Sung Kon Jang Hwan Jong Kim Eunha Park Seung Bum |
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| Institution: | School of Chemistry, Seoul National University, Seoul, 151-747, Korea. |
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| Abstract: | A branching DOS strategy for an unbiased natural product-like library with embedded privileged benzopyran motif was established to provide complexity and diversity of resulting heterocycles with desired drug-likeness. The importance of skeletal diversity conducted on a privileged substructure was demonstrated through the biological evaluation of a small molecule library representing 22 unique core skeletons via in vitro cytotoxicity assay. |
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