Synthesis of 9,10,12,13,14,14a-hexahydrodibenzo[f,h]pyrrolo-[2,1-a]isoquinoline |
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| Authors: | Rodolfo Copado C Mercedes T Grande G Gregorio G Trigo Mnica M Sllhuber K |
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| Institution: | Rodolfo Copado C.,Mercedes T. Grande G.,Gregorio G. Trigo,Mónica M. Söllhuber K |
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| Abstract: | The synthesis of 9,10,12,13,14,14a-hexahydrodibenzof,h]pyrrolo2,1-a]isoquinoline 6 has been accomplished by a sequence involving as a key step the Friedel-Crafts intramolecular acylation of the amino acid 9 to the corresponding pentacyclic aminoketone 10 . Compounds 7, 11 and 12 showed a significant protein synthesis inhibitory effect. |
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