Comparative Study of Some Methods for the Determination of the Analgesic Anti-Inflammatory Compound “IS4”: 4-(Anisylideneamino) Antipyrine

A comparative study of some quantitative methods has been undertaken. Chemical and colorimetric procedures have been developed for the determination of IS₄: 4-(anisylideneamino) antipyrine. The non-aqueous titration and the nitritometric techniques were used. The formation of colored azo dye derivatives through diazotization and coupling with phenolic and amine reagents has been the basis of the colorimetric determination. Statistical analysis of the results has shown that a good agreement of the results has been found on applying the proposed methods to 4-aminoantipyrine.