Convenient synthesis of substituted 3-aminothiophene-2-carbonitriles from α-acetylenic nitriles and their conversion to thieno[3,2-d]pyrimidines |
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Authors: | Wu-Yun Ren Kambhampati V. B. Rao Robert S. Klein |
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Abstract: | Several novel 2,4,6-trisubstituted thieno[3,2-d]pyrimidines were synthesized from the hitherto unknown 3-amino-5-methyl-(or 5-phenyl)thiophene-2-carbonitriles 7 and 8 . o-Aminonitriles 7 and 8 were obtained in a single step by conjugate addition of mercaptoacetonitrile (generated in situ) to substituted acetylenic nitriles 4 and 5 and annelation of the intermediate vinylic thioethers. |
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