Separation of oligo- and polysaccharides by capillary supercritical fluid chromatography

Direct analysis of polar solutes by supercritical fluid chromatography (SFC) has been somewhat limited because the mobile phases in common use are all relatively nonpolar. Derivatization is demonstrated as a viable means for facilitating the SFC separation of sugars. Oligo- and polysaccharides containing up to 18 glucose units are completely resolved by capillary SFC.