Synthesis of 1H-imidazo[1,2-a]imidazole |
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Authors: | Frans Compernolle Suzanne Toppet |
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Abstract: | The synthesis and structure analysis of the unknown 1H-imidazo[1,2-a]imidazole ( 1 ) is described. The preparation involves alkylation of 2-aminoimidazole with bromoacetaldehyde diethyl acetal and subsequent hydrolysis and cyclization with hydrochloric acid. The structure was characterized by mass spectrometry and by 1H-, 15N- and 13C-nmr of 1 and by 1H-nmr of its 1-benzyl derivative 8 . An independent synthesis of 8 was accomplished via cyclization of 2-(N-dichloroethyl-N-benzyl)aminoimidazole ( 11 ). |
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