Studies on the optical analogues of zoapatanol: Synthesis of key intermediate (2S,3R)-2-citronellyl-6-methylene-heptan-2,3,7-triol

The key intermediate (2S, 3R)-2-citronellyl-6-methylene-heptan-2,3,7-triol (8) of analogues of zoapatanol was synthesized in seven steps from the chiral synthon 2. The absolute configuration of the new chiral centre in compounds 5a-8 was identified as S by Mukaiyama's method.