Regioselective alkylation of guanine via diacyloxyglyoxal-N2-acetylguanine adduct to obtain 7-alkylguanine derivatives. Studies on alkylation of guanine I

The acylated guanine-glyoxal adduct (I) has been alkylated with 4-bromobutyl acetate and in the presence of sodium hydride the reaction was regioselective to give 7-alkylguanine.