Addition de la proline à quelques alcènes et alcynes électrophiles

Addition of proline in acetic anhydride to propiolic and pbenylpropiolic ester gave rise to two isomeric pyrroles 5 and 6 . Addition under the same conditions, to electrophilic alkenes pY-PhCH = C(X) (CN) led to a pyrroline-2 8 which eliminated HCN and produced pyrrole 9 . Addition of proline to fumarodinitrile is unusual, the reaction led to a new α-amino acid 10 and compound 11 . The structure of this product 11 was confirmed by X-ray measurements.