First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase |
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| Authors: | Mercey Guillaume Verdelet Tristan Saint-André Géraldine Gillon Emilie Wagner Alain Baati Rachid Jean Ludovic Nachon Florian Renard Pierre-Yves |
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| Institution: | CNRS UMR 6014-COBRA & FR 3038, IRCOF, Rue Lucien Tesnière, 76821 Mont Saint Aignan, France. |
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| Abstract: | Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HL?-7. |
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