Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents |
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| Authors: | Vajpayee Vaishali Yang Yoon Jung Kang Se Chan Kim Hyunuk Kim In Su Wang Ming Stang Peter J Chi Ki-Whan |
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| Institution: | Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea. |
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| Abstract: | Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 and 5, and the tripodal donor 1. The cytotoxicity of 8 was found to be considerably stronger than that of cisplatin. The complex 8 inhibited tumor cell proliferation by interfering into regulatory pathways of the cell cycle via apoptosis. |
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