Development of an irradiation/shielding cavity for in vivo neutron activation analysis of manganese in human bone |
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| Authors: | A Pejović-Milić S H Byun D R Chettle F E McNeill W V Prestwich |
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| Institution: | (1) Ryerson University; Medical Physics and Applied Radiation Sciences Unit, McMaster University, Toronto, M5B 2K3, Canada; Hamilton, L8S 4K1, Canada;(2) Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton, L8S 4K1, Canada;(3) Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton, L8S 4K1, Canada;(4) Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton, L8S 4K1, Canada;(5) Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton, L8S 4K1, Canada |
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| Abstract: | Summary Manganese is essential to human life for normal neurological and skeletal functions. Longstanding, excessive exposure to Mn
compounds may result in manganism, a Parkinson's disease like syndrome. Prolonged exposure to Mn at low levels can result
in memory deficit, loss of motor control and reduction in the refinement of certain bodily motions. A feasibility study of
measuring Mn concentrations in human bone with in vivo neutron activation analysis (IVNAA) was previously reported.1 Since then, an irradiation/shielding cavity, consisting of moderator, gamma-ray filter, neutron reflector, and shield walls,
was constructed for the clinical application of Mn IVNAA,2 and an upgraded IVNAA system is reported here. The minimum detectable limit is 0.081 mg in the hand, which is toward the
lower end of the estimated bone Mn level of 0.065 to 1 mg in the hand of healthy subjects. A significantly lower radiation
dose is delivered than in the reported feasibility study. |
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