Derivatization of aromatic amines with bromine for improved gas chromatographic determination |
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Authors: | T C Schmidt R Haas E von Löw K Steinbach |
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Institution: | (1) Department of Chemistry, Philipps-University, Hans-Meerwein-Strasse, 35032 Marburg, Germany;(2) Environmental hygiene and Immunology, Medical Centre of Hygiene, Pilgrimstein 2, 35037 Marburg, Germany;(3) Bureau for Exploration of Hazardous Waste Sites and Pollution Research, Stadtwaldstrasse 45a, 35037 Marburg, Germany |
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Abstract: | Summary For improved determination of aromatic amines by gas chromatography and detection with an electron capture detector (GC-ECD)
a derivatization method based on the bromination of the aromatic ring in an acetic acid medium was developed. In general,
all free ortho and para-positions relative to the amino group undergo electrophilic substitution. Separation of at least 30
compounds in a single chromatographic run in 30 min is possible. With this method, 56 aromatic amines were studied and only
in 6 cases were no derivatives obtained. Quantitation limits determined from calibration data are 1.2–40 μg L−1 for a 100 mL sample and an injection volume of 1 μL. Previous experiments suggest that both sample and injection volume may
be increased to lower the quantitation limit. |
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Keywords: | Gas chromatography Water analysis Derivatization with bromine Aromatic amines |
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