| Design,synthesis and antitumor activity of 3-substituted quinolone derivatives （Ⅰ） |
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| 作者姓名： | Hua Wang Qi Dong You Zhi Yu Li Yi Quan Zou |
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| 作者单位： | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
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| 基金项目： | The work was supported by National Natural Science Foundation of China （No.30271543）. |
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| 摘 要： | A series of quinolone derivatives containing benzimidazole, benzoxazole or benzothiazole ring were synthesized. The cytotoxicity of 12 new compounds was evaluated in KB, Be17402, A2780 and HT-29 cell lines. Most of synthesized compounds showed moderate inhibitory activity against cancer cells. The inhibitory activities of 6k, against KB and A2780 tumor ceils are comparable to that of topotecan, one of topoisomerase I inhibitors.
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| 关 键 词： | 抗癌抗菌素 苯并咪唑 活性 合成 |
| 收稿时间： | 12 May 2008. |
Design, synthesis and antitumor activity of 3-substituted quinolone derivatives (I) |
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| Hua Wang Qi Dong You Zhi Yu Li Yi Quan Zou.Design, synthesis and antitumor activity of 3-substituted quinolone derivatives (I)[J].Chinese Chemical Letters,2008,19(12):1395-1397. |
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| Authors: | Hua Wang Qi Dong You Zhi Yu Li Yi Quan Zou |
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| Institution: | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | A series of quinolone derivatives containing benzimidazole, benzoxazole or benzothiazole ring were synthesized. The cytotoxicity of 12 new compounds was evaluated in KB, Bel7402, A2780 and HT-29 cell lines. Most of synthesized compounds showed moderate inhibitory activity against cancer cells. The inhibitory activities of 6k, against KB and A2780 tumor cells are comparable to that of topotecan, one of topoisomerase I inhibitors. |
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| Keywords: | Quinolone derivatives Synthesis Antitumor |
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