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Screening method for the evaluation of asymmetric catalysts for the reduction of aliphatic ketones |
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| Authors: | Mourad BoukachabiaSaoussen Zeror Jacqueline Collin Jean-Claude FiaudLouisa Aribi Zouioueche |
| Affiliation: | a Université Paris-Sud, Laboratoire de Catalyse Moléculaire, ICMMO, UMR 8182, Orsay F-91405, France b Equipe de Synthèse Asymétrique et Biocatalyse, LCOA, Université Badji Mokhtar, 23000 Annaba, Algeria c CNRS, Orsay F-91405, France |
| Abstract: | ATH reductions of aliphatic ketones in water catalyzed by ruthenium coordinated by prolinamide ligands produce alcohols with moderate enantiomeric excesses in most cases. A set of seven aliphatic ketones is proposed for a rapid evaluation of the enantioselectivity of catalysts by one-pot multi-substrates reduction. The screening of a library of prolinamides shows that according to the structure of the ketones different ligands give the best asymmetric inductions. |
| Keywords: | Asymmetric catalysis Ruthenium Hydride transfer Multi-substrate screening Aliphatic ketones |
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