| TERNARY Cu(Ⅱ)(ATP)AND HETEROAROMATIC N BASE COMPLEXES IN SOLUTION:STABILITY CONSTANTS AND ANTITUMOR MECHANISM EXPLORATION |
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| 引用本文： | Bin SONG,Jie ZHANG,Liang-Nian JI. TERNARY Cu(Ⅱ)(ATP)AND HETEROAROMATIC N BASE COMPLEXES IN SOLUTION:STABILITY CONSTANTS AND ANTITUMOR MECHANISM EXPLORATION[J]. 中国化学快报, 1992, 3(8): 653-656 |
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| 作者姓名： | Bin SONG Jie ZHANG Liang-Nian JI |
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| 作者单位： | Biotechnology research center, Zhongshan University, Guangzhou 510275 |
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| 基金项目： | This work was supported by The National Nature Science Foundation and the Zhongshan University Science Foundation. |
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| 摘 要： | The stability of the complexes of four pyridine-like ligandswith Cu(ATP)~(2-) was studied and by comparing the stability constants of theternary complexes[Cu(ATP)L]~(2-) with those of the binary complexes[CuL]~(2+),astacking interaction between the pyridine ring and the purine ring of ATP isindicated.It is possible to interpret the antitumor mechanism of[Pt(NH_3)_8(N-het)Cl]Cl in terms of this stacking interaction.
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TERNARY Cu(Ⅱ) (ATP) AND HETEROAROMATIC N BASE COMPLEXES IN SOLUTION:STABILITY CONSTANTS AND ANTITUMOR MECHANISM EXPLORATION |
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| Bin SONG,Jie ZHANG,Liang-Nian JI. TERNARY Cu(Ⅱ) (ATP) AND HETEROAROMATIC N BASE COMPLEXES IN SOLUTION:STABILITY CONSTANTS AND ANTITUMOR MECHANISM EXPLORATION[J]. Chinese Chemical Letters, 1992, 3(8): 653-656 |
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| Authors: | Bin SONG Jie ZHANG Liang-Nian JI |
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| Affiliation: | Biotechnology research center, Zhongshan University, Guangzhou 510275 |
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| Abstract: | The stability of the complexes of four pyridine-like ligands with Cu(ATP)2- was studied and by comparing the stability constants of the ternary complexes [Cu(ATP)L]2- with those of the binary complexes [CuL]2+,a stacking interaction between the pyridine ring and the purine ring of ATP is indicated.It is possible to interpret the antitumor mechanism of[Pt(NH3)8 (N-het)Cl]Cl in terms of this stacking interaction. |
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