| 新药普卢利沙的核磁共振研究 |
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| 引用本文： | 沙沂,李文,张宏杰,杨士颖,贾伟如. 新药普卢利沙的核磁共振研究[J]. 分析化学, 2006, 34(4): 536-538 |
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| 作者姓名： | 沙沂 李文 张宏杰 杨士颖 贾伟如 |
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| 作者单位： | 沈阳药科大学分析测试中心,沈阳,110016;辽宁省医药工业研究院,沈阳,110015 |
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| 摘 要： | 应用同核化学位移相关谱(1H-1H COSY)、氢检出异核多量子相关谱(HMQC)、氢检出多键异核多量子相关谱(HMBC)等二维谱核磁共振技术,参考19F-1H和19F-13C的偶合裂分情况对抗菌新药普卢利沙的1H NMR、13C NMR谱的信号进行了全归属。
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| 关 键 词： | 普卢利沙 核磁共振 信号归属 |
| 收稿时间： | 2005-05-24 |
| 修稿时间： | 2005-05-242005-08-01 |
Nuclear Magnetic Resonance Studies on New Drug Prulifloxacin |
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| Sha Yi,Li Wen,Zhang Hongjie,Yang Shiying,Jia Weiru. Nuclear Magnetic Resonance Studies on New Drug Prulifloxacin[J]. Chinese Journal of Analytical Chemistry, 2006, 34(4): 536-538 |
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| Authors: | Sha Yi Li Wen Zhang Hongjie Yang Shiying Jia Weiru |
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| Affiliation: | 1. Center of Instrumental Analysis, Shenyang Pharmaceutical University, Shenyang 110016 ; 2. Liaonmg Institute of Pharmaceutical Industry, Shenyang 110015 |
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| Abstract: | According to the coupling and splitting of~(19)F-~1H and ~(19)F-~(13)C,the~1H nuclear magnetic resonance(NMR),~(13)C-NMR spectra of prulifloxacin were assigned totally by NMR techniques including homonuclear shift correlation(~1H-~1H COSY),~1H detected heteronuclear multiple-quantum coherence(HMQC) and~1H detected heteronuclear multiple bond coherence(HMBC). |
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| Keywords: | Prulifloxacin nuclear magnetic resonance signal assignment |
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